The Scott Christian College enjoys continuity with a village-church school founded in 1809 at Mylaudy by the  Rev. William Tobias Ringeltaube, the pioneering missionary of the London Missionary Society in South Travancore. This Central School or Seminary was shifted to Nagercoil in 1818 by the Rev. Charles Mead. The Rev. Dr James Duthie took charge of the Seminary in 1860, and played a vital role in raising it to a College. 
The Beginning
In 1893, the Seminary was elevated to a Second Grade College affiliated to the University of Madras with twelve students under Rev Dr James Duthie as the first Principal..

Rev Parker built the Science Block for the College in 1908-1910 with a legacy of £1000 from the family of Mr. Septimus Scott and a grant from the government of Travancore.
The Library was equipped with up-to-date volumes which ran up to 4000 in 1924. During the year 1924-25 in addition to the Literary Associations in English, Tamil and Malayalam, a Science Association was formed and students themselves presided over meetings.
On February 1, 1927, Mr. G.H. Marsden, M.A Tripos of the University of Cambridge took charge as Principal. He took special care in increasing the facilities for the Science Department. By selfless and untiring work he built up the small Intermediate College of about 140 students. Women students in regular batches were admitted from 1927 onwards.
Compulsory games were introduced for the men students in 1927. Scott Christian became the first Mofussil College in the Madras University to have Compulsory Physical Education for men students under a qualified Physical Director with the status of a Lecturer..
When the University of Travancore was established in 1938, the Scott Christian College was admitted to its privileges. By 1943, the number of students in the College had increased to nearly 300 including about 20 women. Since 1948, a period of expansion commenced. The Travancore University sent a Commission which suggested the strength of the Intermediate Classes to be doubled as a prelude to the introduction of degree classes. Mr. A. Nesamony, who had played a distinguished role in Church and public life, took up the responsibility of building the new Degree College block. His persistence, patience and hard work yielded spectacular results. The year 1950 saw the introduction of Degree courses at Scott Christian. The first majors introduced were Mathematics and History, and this was followed by Chemistry (1952), Economics (1954), Physics (1954), Zoology (1956) and B.Sc. Botany (1966).
The college was affiliated to the Madurai University in 1966. In 1967, the Scott Christian College celebrated its 75th Anniversary as the Platinum Jubilee. The Degree Classes were shifted to the New Campus during 1970 -1971.  

George Henry Chapel stands as a monument to the munificence of Mrs. Ida Marsden who after the demise of the legendary principal of the college Mr. Marsden in 1957, contributed their life’s savinghs to Scott Christian College. The Chapel, dedicated to the glory of God in 1986, is the centre for all spiritual and value-based programmes. Besides the daily morning worship, weekly Bible studies and prayer meetings are conducted here.

The College progressively introduced new courses for the undergraduates: B.A. English (1971), B. Com. (1978), B.A. Tamil (1979). The College was affiliated to the University of Madras in 1987. Self-financed B.Sc. Computer Science was introduced in 1997 followed by B.Sc. Physical Education (2002), B.Com. (2002), BBA (2003), BBM (2007), BCA (2007) and B.A. English (2011).
The commencing of post-graduate courses in 1971 was a significant landmark in the history of this College and now there are twelve postgraduate courses in arts, science and commerce subjects. The courses offered at the postgraduate level include M.A. English Literature (1971), M.A. Economics (1971), M.Sc. Zoology (1980), M.Com. (1981), M.Sc. Chemistry (1982), M.Sc. Botany (1983), M.Sc. Physics (1987), M.Sc. Mathematics (1988) and self-financed M.A. History (1992), M. A Tamil (1994), M.Sc. Computer Science (2003), PGDCA (2006), M.Sc. Micro-biology (2007) and PGDBM (2007).
Pre-doctoral (M.Phil) courses were gradually introduced: Zoology (1984), Botany (1986), Economics (1986), Commerce (1991), Tamil (1996), Physics (1996), English (2001), Chemistry (2006), History (2006) and Mathematics (2006).

In 1990, the Madurai University recognized Scott Christian as a Research Centre for Economics and then Zoology (1996), Tamil (1998), Botany (1999), Commerce (2000), English (2003), Chemistry (2004), History (2008), Physics (2010) and Mathematics (2011) were added.Commenced a Web page was in 2011.

The Status of Autonomy was conferred on Scott Christian College, in April 2005, perhaps the most historic moment in the annals of this pioneering seat of higher learning in the South. The NAAC Peer team visit in campus in April 2009 and College was awarded ‘A’ the highest grade. The Ida Marsden Hostel was extended accommodation 500 students in 2009. The UGC has constituted an Expert Committee to evaluate the performance and academic attainments for the Extension of Autonomous Status. The process is expect to be completed within couple of months.

Aims of the College

Scott Christian College aims at giving a liberal Christian education which develops the total personality of the students so that they become worthy citizens of this country with
l understanding and tolerance,
l brotherly love and the
l highest standards of integrity.

The motto of the college,
The truth shall make you free
makes possible the study of the sciences and the human sciences and the social sciences, objectively for the sake of truth.